Prime Calamine Lotion is a topical over-the-counter remedy designed to relieve mild itchiness and skin irritation. This soothing pink lotion effectively alleviates discomfort caused by bug bites, chickenpox, poisonous plants, and more. The zinc in calamine lotion has anti-inflammatory properties that help reduce skin redness and soothe irritation. When applied, the aqueous component of the lotion evaporates, drawing heat from the body and creating a cooling effect at the application site. This process provides both soothing and antipruritic benefits, helping to calm the skin.